### 1. Correction with Known $$\mu$$

• Our estimate for $$\mu$$ is unbiased but has a fairly large variance.

• I have preliminary results showing that our method of averaging results over all SNPs works when the true effect at the CV ($$\mu$$) is known and used in $$Z_j$$.

• I check these results using UK10K data and low, medium and high LD regions using the 1000 genomes data.

• These results are in the 24july/knownmu/ directory.

#### UK10K Data

Number of simulations making up each bin:

##
##    (0,1]    (1,2]  (2,2.5]  (2.5,3]    (3,4] (4,4.75] (4.75,6]    (6,8]
##      262      453      264      310      665      436      665      666
##   (8,13]  (13,16] (16,Inf]
##      680      254      270

#### 1000 Genomes Data

Now for the high/medium/low LD regions using 1000 genomes data: