Variance of the estimated effect size for case-control data

Variance of the estimated effect size for case-control data

Var.data.cc(f, N, s)

Arguments

f	Minor allele frequencies
N	Total sample size (N0+N1)
s	Proportion of cases (N1/N0+N1)

Value

Variance of estimated effect size \(\hat{\beta}\), V.

Examples

maf =  runif(100, 0.05, 0.5)
N0 = 5000 # number of controls
N1 = 5000 # number of cases

Var.data.cc(f = maf, N = N0 + N1, s = N1/(N0+N1))
#>   [1] 0.0025353881 0.0008181891 0.0009185978 0.0018838648 0.0039615189
#>   [6] 0.0010398200 0.0010054095 0.0013526966 0.0008490723 0.0008349987
#>  [11] 0.0008103213 0.0017832687 0.0032716992 0.0012781987 0.0011257163
#>  [16] 0.0016807679 0.0011238656 0.0027600597 0.0011472589 0.0008003876
#>  [21] 0.0013523677 0.0008731582 0.0008481271 0.0016794491 0.0008002455
#>  [26] 0.0008457706 0.0029498620 0.0009741453 0.0008648122 0.0008682137
#>  [31] 0.0033360702 0.0015558156 0.0013244121 0.0008959042 0.0010254392
#>  [36] 0.0010827900 0.0008600363 0.0008017172 0.0017551329 0.0015896011
#>  [41] 0.0008722764 0.0010043137 0.0008928560 0.0008824952 0.0023662309
#>  [46] 0.0008372615 0.0008359197 0.0008000559 0.0008005635 0.0011464753
#>  [51] 0.0010459693 0.0012899149 0.0017846766 0.0009729199 0.0010097017
#>  [56] 0.0008328569 0.0016427071 0.0008570213 0.0027378034 0.0012081117
#>  [61] 0.0008203023 0.0013965148 0.0009408861 0.0012449967 0.0009216941
#>  [66] 0.0017001414 0.0008017721 0.0009633361 0.0009615185 0.0013829869
#>  [71] 0.0010637900 0.0011763816 0.0034068508 0.0010402951 0.0011450982
#>  [76] 0.0036006916 0.0011668847 0.0009488545 0.0008134581 0.0011536551
#>  [81] 0.0009762270 0.0009186820 0.0014334696 0.0013519527 0.0010242762
#>  [86] 0.0008041682 0.0011281913 0.0016047137 0.0008764885 0.0028351501
#>  [91] 0.0008000056 0.0019349560 0.0009849161 0.0008156441 0.0008549669
#>  [96] 0.0014987998 0.0009594483 0.0008180840 0.0034092500 0.0010363472